Confirmation bias and New Thought

“By 1890, this stream of religious philosophy had morphed into a set of mystical beliefs in the power of thought to affect the material world beyond the self”

“Elements of New Thought have recently seeped into strategic thinking through literature on leadership and vision”

Excerpt From: Rumelt, Richard. “Good Strategy/Bad Strategy”. Apple Books.

also, confirmation bias from Fooled by Randomness, who has made money feels optimist until maybe they blow, maybe they don’t.

Blitzscaling Hero or Lockean Titan, whatever

“Being a successful Lockean Titan is like being the successful staph bacterium that manages to find its way into a break in its host’s skin and spawn an infection: yes, you had all the characteristics necessary to go viral (ahem), but you also got lucky by being in the right place at the right time, and if you hadn’t been there, someone else would have been.”

Thanks Doctorow, great writers are there to give voice to your thoughts, I had been looking for an image like this to describe innovation in the age of the unicorns, and why geography matters, and what is the real role of the hero in a world well set by technology and finance

Cory Doctorow: Terra Nullius

Less money, more success, to be confirmed

“The fact is that the amount of money startups raise in their seed and Series A rounds is inversely correlated with success. Yes, I mean that. Less money raised leads to more success. That is the data I stare at all the time. It makes little sense at face value but it is true based on more than two decades of experience in the startup world.”

Fred Wilson “Maximizing runaway can minimize success”

Fred has the data, 20 years of it, in front of him but I can’t find it, duh

Break things to move fast

Move fast, break things – Zuckerberg

an old, beautiful story where breaking things, or breaking the tasks into the smallest pieces helped move fast, or faster

“Boyer’s plan for the synthesis of insulin was almost comically simple. He did not have the gene for human insulin at hand—no one did—but he would build it from scratch using DNA chemistry, nucleotide by nucleotide, triplet upon triplet—ATG, CCC, TCC, and so forth, all the way from the first triplet code to the last. He would make one gene for the A chain, and another gene for the B chain. He would insert both the genes in bacteria and trick them into synthesising the human proteins. He would purify the two protein chains and then stitch them chemically to obtain the U-shaped molecule.”

Excerpt From: Siddhartha Mukherjee. “The Gene”.

(…) Gilbert “had for many days past, trudging through an airlock, dipping his shoes in formaldehyde on his way into the chamber in which he was obliged to conduct his experiments. Out at Genentech, we were simply synthesizing DNA and throwing it into bacteria, none of which even required compliance with the NIH guidelines.” In the world of post-Asilomar genetics, “being natural” had turned out to be a liability.”

Excerpt From: Siddhartha Mukherjee. “The Gene”.

and BTW sometimes it is an advantage a surname starting with A or B

“He had dug up a dog-eared handbook from the Asilomar meeting, made a list of important players working on gene-cloning techniques, and had started working down the list alphabetically. Berg came before Boyer—but Berg, who had no patience for opportunistic entrepreneurs making cold calls to his lab, turned Swanson down. Swanson swallowed his pride and kept going down the list. B . . . Boyer was next.”

Excerpt From: Siddhartha Mukherjee. “The Gene”.

“On October 26, 1982, the US Patent and Trademark Office (USPTO) issued a patent to Genentech to use recombinant DNA to produce a protein such as insulin or somatostatin in a microbial organism. As one observer wrote: “effectively, the patent claimed, as an invention, [all] genetically modified microorganisms.” The Genentech patent would soon become one of the most lucrative, and most hotly disputed, patents in the history of technology.”

Excerpt From: Siddhartha Mukherjee. “The Gene”. Apple Books.