Less money, more success, to be confirmed

“The fact is that the amount of money startups raise in their seed and Series A rounds is inversely correlated with success. Yes, I mean that. Less money raised leads to more success. That is the data I stare at all the time. It makes little sense at face value but it is true based on more than two decades of experience in the startup world.”

Fred Wilson “Maximizing runaway can minimize success”

Fred has the data, 20 years of it, in front of him but I can’t find it, duh

Of chimeras and their prices

Novartis Kymriah, a single dose is priced at $475,000. Steep price for a medicine, or is it a medicine ?

It is CAR-T therapy that is developed to target an increasing number of cancers

“And these price tags don’t include the delivery of post-therapy care to CAR-T patients, who typically suffer complications from the infusion. Subsequent hospital stays and supportive care can drive the total costs to a million dollars or more. Merely counting the seventy-five hundred U.S. patients who meet the current F.D.A. indications for Yescarta, the estimated annual expenditure could be three billion dollars.”

Biggest business in town, thats Why we are investing in Tmunity

Quote above is from Siddhartha Mukherjee The Promise and Price of Cellular Therapies

I am curious to know how you market and deliver a “medicine” like Kymriah

-Cost considerations: even if we treat as a procedure and not a medicine CAR-T can have 6- figures cost (Kymriah introduced a world first: performace therapy, pay if satisfied)

-treating it as a medicine could stiffen marginal improvements, procedures on the other end have more lax approval for small ietrative improvements

-a medicine is manifactured, a procedure is a surgeon’s craft, unless a way is found to mass manifacture CAR-T there will be conflicts

Cytokine Storm

Cellicon Valley



the idea that AI reinforces totalitarian weaknesses

Fear not China, Seeing Like a Finite State Machine

“The theory behind this is one of strength reinforcing strength – the strengths of ubiquitous data gathering and analysis reinforcing the strengths of authoritarian repression to create an unstoppable juggernaut of nearly perfectly efficient oppression. Yet there is another story to be told – of weakness reinforcing weakness. Authoritarian states were always particularly prone to the deficiencies identified in James Scott’s Seeing Like a State – the desire to make citizens and their doings legible to the state, by standardizing and categorizing them, and reorganizing collective life in simplified ways, for example by remaking cities so that they were not organic structures that emerged from the doings of their citizens, but instead grand chessboards with ordered squares and boulevards, reducing all complexities to a square of planed wood

The latest link is where Italo Calvino can be used as perfect metaphor of epistemic confrontation in the field of politics

Climate tipping points

Climate tipping points — too risky to bet against

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tech people fixation with tunnels

“for example, when New York decided to build the subway in 1900: 4.7 years later, they opened 23 subway stations, and in 2019 dollars, they spent just over a billion dollars doing so. So 23 stations, just over a billion dollars”

Relative abundances and scarcities define the economic times, I would for example expect that NY 1900 would be abundant of  cheap workforce employable at very flexible terms, which I am sure it is not true today where most people works in services and with much higher protections on the job

The quote was from Patrick Collison, founder of Stripe in a chat with Tyler Cowen and Mark Zuckerberg https://medium.com/conversations-with-tyler/mark-zuckerberg-interviews-patrick-collison-and-tyler-cowen-on-the-nature-and-causes-of-progress-30de2e2c48f2

My opinion is just general but I think in the right direction. one has to understand what drives development and growth, and today it’s not what it was 120 years ago. In 50 times someone will muse the good old days when Mark could amass 2 billion users in 15 years while now no matter how much money you spend you might expect just 2 o 3 hunderd millions. Oh cruel times, we are so bad compared to the intenret pionners, glossing over the fact that the users will have much more protection from spam and aggressive marketing (yeah, pipedream)

gullible, unprotected users is the relative abundance of our times

link full of tunnels prices https://nypost.com/2018/08/25/why-nyc-is-priciest-city-in-the-world-for-infrastructure-projects/

I said tech people fixation with tunnels, let’s not forget that one day Musk, frustrated with the time it takes to build tunnels today, bought a boring machine and started digging a hole under his company’s parking.

Yes! Tyler Cowen on Subway Cost Desease

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Wealth and charity US

Rich people propensity to philanthropy same as general population, exceptions Buffet & Gates

Bezos tax rate is )% it is extreme but most 0,01% rich pay less