Ordoliberalism

nice writeup https://sweettalkconversation.com/2015/01/01/ordoliberalism-and-the-myth-of-laissez-faire/amp/

Tyler Cowen advocates state-capacity libertarianism https://marginalrevolution.com/marginalrevolution/2020/01/what-libertarianism-has-become-and-will-become-state-capacity-libertarianism.html

Cartels in pre-war Germany, from Competition Policy in Germany

Screenshot 2020-01-28 at 16.03.01

Helicopter VC Money

1. some says the stock market has matured, all blue chips company are pretty much well managed, so it does not really matter picking the right one, so passive investing

2. But some other noted that if you take out the value created by a 4% of high-performers the rest of the pubblic companies just thred water, so pick thos 4% and grow rich. So pick the google and facebook early. Buy a crystal ball

3. Or just get into any seed round you can, because someone says this is the best way to gt into those winners

1. would Maubouissin in this paper The Incredible Shrinking Universe of Stocks

2. would be The best-performing four percent of listed companies explain the net gain for the entire U.S. stock market since 1926, as other stocks collectively matched Treasury bills

3. is Angel List If you miss the best-performing seed investment, you will eventually be outperformed by someone who blindly invests in every credible deal.

 

Less money, more success, to be confirmed

“The fact is that the amount of money startups raise in their seed and Series A rounds is inversely correlated with success. Yes, I mean that. Less money raised leads to more success. That is the data I stare at all the time. It makes little sense at face value but it is true based on more than two decades of experience in the startup world.”

Fred Wilson “Maximizing runaway can minimize success”

Fred has the data, 20 years of it, in front of him but I can’t find it, duh

Of chimeras and their prices

Novartis Kymriah, a single dose is priced at $475,000. Steep price for a medicine, or is it a medicine ?

It is CAR-T therapy that is developed to target an increasing number of cancers

“And these price tags don’t include the delivery of post-therapy care to CAR-T patients, who typically suffer complications from the infusion. Subsequent hospital stays and supportive care can drive the total costs to a million dollars or more. Merely counting the seventy-five hundred U.S. patients who meet the current F.D.A. indications for Yescarta, the estimated annual expenditure could be three billion dollars.”

Biggest business in town, thats Why we are investing in Tmunity

Quote above is from Siddhartha Mukherjee The Promise and Price of Cellular Therapies

I am curious to know how you market and deliver a “medicine” like Kymriah

-Cost considerations: even if we treat as a procedure and not a medicine CAR-T can have 6- figures cost (Kymriah introduced a world first: performace therapy, pay if satisfied)

-treating it as a medicine could stiffen marginal improvements, procedures on the other end have more lax approval for small ietrative improvements

-a medicine is manifactured, a procedure is a surgeon’s craft, unless a way is found to mass manifacture CAR-T there will be conflicts

Cytokine Storm

Cellicon Valley

 

 

the idea that AI reinforces totalitarian weaknesses

Fear not China, Seeing Like a Finite State Machine

“The theory behind this is one of strength reinforcing strength – the strengths of ubiquitous data gathering and analysis reinforcing the strengths of authoritarian repression to create an unstoppable juggernaut of nearly perfectly efficient oppression. Yet there is another story to be told – of weakness reinforcing weakness. Authoritarian states were always particularly prone to the deficiencies identified in James Scott’s Seeing Like a State – the desire to make citizens and their doings legible to the state, by standardizing and categorizing them, and reorganizing collective life in simplified ways, for example by remaking cities so that they were not organic structures that emerged from the doings of their citizens, but instead grand chessboards with ordered squares and boulevards, reducing all complexities to a square of planed wood”

The latest link is where Italo Calvino can be used as perfect metaphor of epistemic confrontation in the field of politics